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The original City Memorial Hospital of Thomasville opened its doors in July 1930 with 31 beds organized by community leaders TA Finch, C.H. Phillips, Doak Finch, James R. Lambeth, and A. H. Ragan. In 1934, the Nurses' Home adjacent to the Hospital was built.

The hospital opened the first Intensive Care Unit in the area in 1966 to give specialized care to coronary and critically ill patients. The nearest intensive care units before the unit opened were at Duke, NC Memorial, Baptist and Charlotte Memorial hospitals. The hospital also pioneered one of the first cardiac rehabilitation programs in the area when they established Piedmont Cardiac Rehab located at the Tom A. Finch Community YMCA.

In 1967 the Hospital Guild of Thomasville was formed. This volunteer group played an important role in the development of the medical center purchasing major equipment, establishing the Hospitality Shop, co-sponsoring An Evening of Music and the establishment of an educational scholarship to assist those going into the medical field as part of the Guild legacy.

January 1, 1971 the hospital name was officially changed to Community General Hospital of Thomasville. The facility was moved to a new location August 7,1971 after a $1.5 million community fund drive. A new emergency room, outpatient surgery department and radiology department were added in 1983. In 1986, the Outpatient Cancer Treatment Center opened to bring cancer services close to home for patients and families. In 1988, the new intensive care, coronary care and pediatric units were opened. In September 1988, The Learning Place opened, establishing Community General as one of the first triad hospitals to etablish onsite child care. In November 1997, Community General merged with Novant Health, joining Forsyth Medical Center in Winston Salem and Presbyterian Healthcare in Charlotte.

In March 2001 Thomasville Medical Center officially changed its name to Thomasville Medical Center, and in June opened the largest addition since moving to its present site. The $9.3 million dollar expansion included state of the art operating rooms, an outpatient multispecialty clinic, and renovation of an existing 31 thousand square feet. To better meet the healthcare needs of the community the medical center also established centers of excellence to focus on specific healthcare issues including the Sleep Disorders Center, the Chestpain Center, the Total Joint Center and the Spine Center, all of which combine the latest treatment options with a team of medical experts.